Simona Di Lascio Selected Research

Congenital central hypoventilation syndrome

4/2022	Etonogestrel Administration Reduces the Expression of PHOX2B and Its Target Genes in the Solitary Tract Nucleus.
1/2022	Generation of two hiPSC lines (UMILi027-A and UMILi028-A) from early and late-onset Congenital Central hypoventilation Syndrome (CCHS) patients carrying a polyalanine expansion mutation in the PHOX2B gene.
1/2019	Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation.
6/2016	Alanine Expansions Associated with Congenital Central Hypoventilation Syndrome Impair PHOX2B Homeodomain-mediated Dimerization and Nuclear Import.
2/2013	Transcriptional dysregulation and impairment of PHOX2B auto-regulatory mechanism induced by polyalanine expansion mutations associated with congenital central hypoventilation syndrome.
9/2012	The E3 ubiquitin ligase TRIM11 mediates the degradation of congenital central hypoventilation syndrome-associated polyalanine-expanded PHOX2B.
1/2012	In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins.

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Simona Di Lascio Research Topics

Disease

7	Congenital central hypoventilation syndrome 04/2022 - 01/2012
5	Breast Neoplasms (Breast Cancer) 10/2021 - 06/2013
4	Neoplasms (Cancer) 01/2021 - 06/2015
3	Neuroblastoma 01/2018 - 09/2012
2	Hypercapnia 04/2022 - 01/2012
2	Nervous System Diseases (Neurological Disorders) 04/2022 - 04/2021
2	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2021
2	Neoplasm Metastasis (Metastasis) 01/2018 - 02/2014
1	Hypoventilation 04/2022
1	Neuralgia (Stump Neuralgia) 11/2021
1	Chronic Pain 11/2021
1	Cognitive Dysfunction 04/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2021
1	Neuroinflammatory Diseases 04/2021
1	Alzheimer Disease (Alzheimer's Disease) 04/2021
1	Lung Neoplasms (Lung Cancer) 01/2018
1	Adenocarcinoma 01/2018
1	Sarcoidosis (Schaumann Disease) 01/2017
1	Mental Disorders (Mental Disorder) 11/2016
1	Weight Gain 06/2013
1	Hypoxia (Hypoxemia) 01/2012

Drug/Important Bio-Agent (IBA)

5	polyalanineIBA 01/2022 - 01/2012
2	NBPhox proteinIBA 04/2022 - 01/2019
2	LigandsIBA 01/2022 - 11/2016
2	Choline (Choline Chloride)IBA 04/2021 - 01/2021
2	Nicotine FDA Link 01/2021 - 01/2018
2	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2012
1	Ammonium CompoundsIBA 01/2022
1	StilbenesIBA 01/2022
1	Acetylcarnitine (Alcar)IBA 11/2021
1	Analgesics (Analgesic Drugs)IBA 11/2021
1	Acetylcholine (Acetylcholine Chloride)FDA Link 04/2021
1	Cholinergic Agents (Cholinergics)IBA 04/2021
1	EsterasesIBA 04/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	NucleotidesIBA 01/2021
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2021
1	Temozolomide (Temodar)FDA LinkGeneric 01/2021
1	Peptides (Polypeptides)IBA 01/2018
1	Progesterone FDA LinkGeneric 01/2018
1	etonogestrel (Implanon)FDA Link 01/2018
1	Cholinergic ReceptorsIBA 01/2018
1	CarcinogensIBA 01/2018
1	SmokeIBA 01/2018
1	Desogestrel FDA LinkGeneric 01/2018
1	Letrozole (Femara)FDA LinkGeneric 01/2017
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2017
1	Oxytocin (Pitocin)FDA LinkGeneric 11/2016
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2016
1	Alanine (L-Alanine)FDA Link 06/2016
1	Homeodomain Proteins (Proteins, Homeobox)IBA 03/2016
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 03/2016
1	Aromatase InhibitorsIBA 06/2015
1	Tamoxifen FDA LinkGeneric 06/2015
1	Estrogen ReceptorsIBA 06/2015
1	Hormones (Hormone)IBA 06/2013
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 09/2012

Therapy/Procedure

5	Therapeutics 10/2021 - 06/2013
1	Mastectomy (Mammectomy) 01/2021